Structural basis for membrane fusion by enveloped viruses.

  title={Structural basis for membrane fusion by enveloped viruses.},
  author={Winfried Weissenhorn and Andr{\'e}a Dessen and Lesley J. Calder and Stephen C Harrison and John J. Skehel and Don C. Wiley},
  journal={Molecular membrane biology},
  volume={16 1},
Enveloped viruses such as HIV-1, influenza virus, and Ebola virus express a surface glycoprotein that mediates both cell attachment and fusion of viral and cellular membranes. The membrane fusion process leads to the release of viral proteins and the RNA genome into the host cell, initiating an infectious cycle. This review focuses on the HIV-1 gp41 membrane fusion protein and discusses the structural similarities of viral membrane fusion proteins from diverse families such as Retroviridae (HIV… CONTINUE READING