Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a

@article{Russo1998StructuralBF,
  title={Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a},
  author={Alicia A. Russo and Lily Tong and J. O. Lee and Philip D. Jeffrey and Nikola P Pavletich},
  journal={Nature},
  year={1998},
  volume={395},
  pages={237-243}
}
The cyclin-dependent kinases 4 and 6 (Cdk4/6) that control the G1 phase of the cell cycle and their inhibitor, the p16INK4a tumour suppressor, have a central role in cell proliferation and in tumorigenesis. The structures of Cdk6 bound to p16INK4a and to the related p19INK4d reveal that the INK4 inhibitors bind next to the ATP-binding site of the catalytic cleft, opposite where the activating cyclin subunit binds. They prevent cyclin binding indirectly by causing structural changes that… Expand

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