Structural basis for inhibiting β-amyloid oligomerization by a non-coded β-breaker-substituted endomorphin analogue.

@article{FrydmanMarom2011StructuralBF,
  title={Structural basis for inhibiting β-amyloid oligomerization by a non-coded β-breaker-substituted endomorphin analogue.},
  author={Anat Frydman-Marom and Marino Convertino and Riccardo Pellarin and Ayala Lampel and Ronit Shaltiel-Karyo and Daniel Segal and Amedeo Caflisch and Deborah E. Shalev and Ehud Gazit},
  journal={ACS chemical biology},
  year={2011},
  volume={6 11},
  pages={1265-76}
}
The distribution of endomorphins (EM) 1 and 2 in the human brain inversely correlates with cerebral neurodegeneration in Alzheimer's disease (AD), implying a protective role. These endogenous opioid peptides incorporate aromatic residues and a β-breaker motif, as seen in several optimized inhibitors of Aβ aggregation. The activity of native endomorphins was studied, as well as the rationally designed analogue Aib-1, which includes a remarkably efficient β-breaker, α-aminoisobutyric acid (Aib… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 64 references

Alzheimer's disease.

The New England journal of medicine • 2010

Similar Papers

Loading similar papers…