Structural basis for inactivation of Giardia lamblia carbamate kinase by disulfiram.

Abstract

Carbamate kinase from Giardia lamblia is an essential enzyme for the survival of the organism. The enzyme catalyzes the final step in the arginine dihydrolase pathway converting ADP and carbamoyl phosphate to ATP and carbamate. We previously reported that disulfiram, a drug used to treat chronic alcoholism, inhibits G. lamblia CK and kills G. lamblia… (More)
DOI: 10.1074/jbc.M114.553123

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