Structural basis for hygromycin B inhibition of protein biosynthesis.

  title={Structural basis for hygromycin B inhibition of protein biosynthesis.},
  author={Maria A Borovinskaya and Shinichiro Shoji and Kurt Fredrick and Jamie H D Cate},
  volume={14 8},
Aminoglycosides are one of the most widely used and clinically important classes of antibiotics that target the ribosome. Hygromycin B is an atypical aminoglycoside antibiotic with unique structural and functional properties. Here we describe the structure of the intact Escherichia coli 70S ribosome in complex with hygromycin B. The antibiotic binds to the mRNA decoding center in the small (30S) ribosomal subunit of the 70S ribosome and induces a localized conformational change, in contrast to… CONTINUE READING


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