Structural basis for gluten intolerance in celiac sprue.

  title={Structural basis for gluten intolerance in celiac sprue.},
  author={Lu Shan and \Oyvind Molberg and Isabelle Parrot and Felix Hausch and Ferda Filiz and Gary M. Gray and Ludvig M. Sollid and Chaitan Khosla},
  volume={297 5590},
Celiac Sprue, a widely prevalent autoimmune disease of the small intestine, is induced in genetically susceptible individuals by exposure to dietary gluten. A 33-mer peptide was identified that has several characteristics suggesting it is the primary initiator of the inflammatory response to gluten in Celiac Sprue patients. In vitro and in vivo studies in rats and humans demonstrated that it is stable toward breakdown by all gastric, pancreatic, and intestinal brush-border membrane proteases… CONTINUE READING
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