Structural basis for gate-DNA recognition and bending by type IIA topoisomerases

@article{Dong2007StructuralBF,
  title={Structural basis for gate-DNA recognition and bending by type IIA topoisomerases},
  author={K. Dong and J. Berger},
  journal={Nature},
  year={2007},
  volume={450},
  pages={1201-1205}
}
Type II topoisomerases disentangle DNA to facilitate chromosome segregation, and represent a major class of therapeutic targets. Although these enzymes have been studied extensively, a molecular understanding of DNA binding has been lacking. Here we present the structure of a complex between the DNA-binding and cleavage core of Saccharomyces cerevisiae Topo II (also known as Top2) and a gate-DNA segment. The structure reveals that the enzyme enforces a 150° DNA bend through a mechanism similar… Expand
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References

SHOWING 1-10 OF 52 REFERENCES
DNA transport by a type II topoisomerase: direct evidence for a two-gate mechanism.
...
1
2
3
4
5
...