Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase

Abstract

The polyketide natural product borrelidin displays antibacterial, antifungal, antimalarial, anticancer, insecticidal and herbicidal activities through the selective inhibition of threonyl-tRNA synthetase (ThrRS). How borrelidin simultaneously attenuates bacterial growth and suppresses a variety of infections in plants and animals is not known. Here we show… (More)
DOI: 10.1038/ncomms7402

Topics

7 Figures and Tables

Blog articles referencing this paper