Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase


The polyketide natural product borrelidin displays antibacterial, antifungal, antimalarial, anticancer, insecticidal and herbicidal activities through the selective inhibition of threonyl-tRNA synthetase (ThrRS). How borrelidin simultaneously attenuates bacterial growth and suppresses a variety of infections in plants and animals is not known. Here we show… (More)
DOI: 10.1038/ncomms7402


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