Structural basis for eliciting a cytotoxic effect in HER2-overexpressing cancer cells via binding to the extracellular domain of HER2.

@article{Jost2013StructuralBF,
  title={Structural basis for eliciting a cytotoxic effect in HER2-overexpressing cancer cells via binding to the extracellular domain of HER2.},
  author={Christian Jost and Johannes Schilling and Rastislav Tamaskovic and Martin Schwill and Annemarie Honegger and Andreas Pl{\"u}ckthun},
  journal={Structure},
  year={2013},
  volume={21 11},
  pages={1979-91}
}
Human epidermal growth factor receptor-2 (HER2) is a receptor tyrosine kinase directly linked to the growth of malignancies from various origins and a validated target for monoclonal antibodies and kinase inhibitors. Utilizing a new approach with designed ankyrin repeat proteins (DARPins) as alternative binders, we show that binding of two DARPins connected… CONTINUE READING