Structural basis for diversity in the SAM clan of riboswitches.

  title={Structural basis for diversity in the SAM clan of riboswitches.},
  author={Jeremiah J Trausch and Zhenjiang Xu and Andrea L. Edwards and Francis E. Reyes and Phillip E. Ross and Rob Knight and Robert T Batey},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={111 18},
In bacteria, sulfur metabolism is regulated in part by seven known families of riboswitches that bind S-adenosyl-l-methionine (SAM). Direct binding of SAM to these mRNA regulatory elements governs a downstream secondary structural switch that communicates with the transcriptional and/or translational expression machinery. The most widely distributed SAM-binding riboswitches belong to the SAM clan, comprising three families that share a common SAM-binding core but differ radically in their… CONTINUE READING
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