Structural basis for dimerization of ICAM-1 on the cell surface.

  title={Structural basis for dimerization of ICAM-1 on the cell surface.},
  author={Yuting Yang and C. Blattn{\'y} Jun and Jin-huan Liu and Rongguang Zhang and Andrzej Joachimiak and Timothy A Springer and Jia-Huai Wang},
  journal={Molecular cell},
  volume={14 2},
We have determined the 3.0 A crystal structure of the three C-terminal domains 3-5 (D3-D5) of ICAM-1. Combined with the previously known N-terminal two-domain structure (D1D2), a model of an entire ICAM-1 extracellular fragment has been constructed. This model should represent a general architecture of other ICAM family members, particularly ICAM-3 and ICAM-5. The observed intimate dimerization interaction at D4 and a stiff D4-D5 stem-like architecture provide a good structural explanation for… CONTINUE READING

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