Structural basis for developmentally regulated changes in cadherin function at synapses.

@article{Elste2006StructuralBF,
  title={Structural basis for developmentally regulated changes in cadherin function at synapses.},
  author={Alice M Elste and Deanna L. Benson},
  journal={The Journal of comparative neurology},
  year={2006},
  volume={495 3},
  pages={324-35}
}
Members of the cadherin family of calcium-dependent cell adhesion molecules can bind homophilically across central nervous system (CNS) synapses, but experimental evidence indicates the nature of their contribution to synapse structure and function changes over time. We asked whether changes in function correspond to differences in intrasynaptic distribution. Using quantitative immuno-electronmicroscopy, we determined where cadherins are localized within synapses at key developmental stages in… CONTINUE READING

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