Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1.

@article{Donovan2013StructuralBF,
  title={Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1.},
  author={Jesse Donovan and Matthew Dufner and Alexei V. Korennykh},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 5},
  pages={1652-7}
}
The human sensor of double-stranded RNA (dsRNA) oligoadenylate synthetase 1 (hOAS1) polymerizes ATP into 2',5'-linked iso-RNA (2-5A) involved in innate immunity, cell cycle, and differentiation. We report the crystal structure of hOAS1 in complex with dsRNA and 2'-deoxy ATP at 2.7 Å resolution, which reveals the mechanism of cytoplasmic dsRNA recognition and activation of oligoadenylate synthetases. Human OAS1 recognizes dsRNA using a previously uncharacterized protein/RNA interface that forms… CONTINUE READING
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