Structural basis for conductance through TRIC cation channels

  title={Structural basis for conductance through TRIC cation channels},
  author={Min Su and Feng Gao and Qi Yuan and Yang Mao and De-lin Li and Youzhong Guo and Cheng Yang and Xiao-hui Wang and Renato Bruni and Brian Kloss and Hong Zhao and Yang Zeng and Faben Zhang and Andrew R. Marks and Wayne A. Hendrickson and Yu-hang Chen},
  journal={Nature Communications},
Mammalian TRICs function as K+-permeable cation channels that provide counter ions for Ca2+ handling in intracellular stores. Here we describe the structures of two prokaryotic homologues, archaeal SaTRIC and bacterial CpTRIC, showing that TRIC channels are symmetrical trimers with transmembrane pores through each protomer. Each pore holds a string of water molecules centred at kinked helices in two inverted-repeat triple-helix bundles (THBs). The pores are locked in a closed state by a… 

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