Structural basis for co-stimulation by the human CTLA-4/B7-2 complex

@article{Schwartz2001StructuralBF,
  title={Structural basis for co-stimulation by the human CTLA-4/B7-2 complex},
  author={J D Schwartz and Xuewu Zhang and Alexander A. Fedorov and Stanley G. Nathenson and Steven C. Almo},
  journal={Nature},
  year={2001},
  volume={410},
  pages={604-608}
}
Regulation of T-cell activity is dependent on antigen-independent co-stimulatory signals provided by the disulphide-linked homodimeric T-cell surface receptors, CD28 and CTLA-4 (ref. 1). Engagement of CD28 with B7-1 and B7-2 ligands on antigen-presenting cells (APCs) provides a stimulatory signal for T-cell activation, whereas subsequent engagement of CTLA-4 with these same ligands results in attenuation of the response. Given their central function in immune modulation, CTLA-4- and CD28… CONTINUE READING
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