Structural basis for cisplatin DNA damage tolerance by human polymerase η during cancer chemotherapy


A major clinical problem in the use of cisplatin to treat cancers is tumor resistance. DNA polymerase η (Pol-η) is a crucial polymerase that allows cancer cells to cope with the cisplatin–DNA adducts that are formed during chemotherapy. We present here a structure of human Pol-η inserting deoxycytidine triphosphate (dCTP) opposite a cisplatin intrastrand… (More)
DOI: 10.1038/nsmb.2295

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