Structural basis for cisplatin DNA damage tolerance by human polymerase η during cancer chemotherapy

Abstract

A major clinical problem in the use of cisplatin to treat cancers is tumor resistance. DNA polymerase η (Pol-η) is a crucial polymerase that allows cancer cells to cope with the cisplatin–DNA adducts that are formed during chemotherapy. We present here a structure of human Pol-η inserting deoxycytidine triphosphate (dCTP) opposite a cisplatin intrastrand… (More)
DOI: 10.1038/nsmb.2295

4 Figures and Tables

Topics

  • Presentations referencing similar topics