Structural basis for cell cycle checkpoint control by the BRCA1-CtIP complex.

@article{Varma2005StructuralBF,
  title={Structural basis for cell cycle checkpoint control by the BRCA1-CtIP complex.},
  author={A. Varma and Raymond S. Brown and G. Birrane and J. Ladias},
  journal={Biochemistry},
  year={2005},
  volume={44 33},
  pages={
          10941-6
        }
}
The breast and ovarian tumor suppressor BRCA1 has important functions in cell cycle checkpoint control and DNA repair. Two tandem BRCA1 C-terminal (BRCT) domains are essential for the tumor suppression activity of BRCA1 and interact in a phosphorylation-dependent manner with proteins involved in DNA damage-induced checkpoint control, including the DNA helicase BACH1 and the CtBP-interacting protein (CtIP). The crystal structure of the BRCA1 BRCT repeats bound to the PTRVSpSPVFGAT phosphopeptide… Expand
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