Structural basis for catalysis and inhibition of N-glycan processing class I alpha 1,2-mannosidases.

@article{Valle2000StructuralBF,
  title={Structural basis for catalysis and inhibition of N-glycan processing class I alpha 1,2-mannosidases.},
  author={François Vall{\'e}e and Khanita Karaveg and Annette Herscovics and Kelley W Moremen and P Lynne Howell},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 52},
  pages={41287-98}
}
Endoplasmic reticulum (ER) class I alpha1,2-mannosidase (also known as ER alpha-mannosidase I) is a critical enzyme in the maturation of N-linked oligosaccharides and ER-associated degradation. Trimming of a single mannose residue acts as a signal to target misfolded glycoproteins for degradation by the proteasome. Crystal structures of the catalytic domain of human ER class I alpha1,2-mannosidase have been determined both in the presence and absence of the potent inhibitors kifunensine and 1… CONTINUE READING
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