Structural basis for autoactivation of human Mst2 kinase and its regulation by RASSF5.

@article{Ni2013StructuralBF,
  title={Structural basis for autoactivation of human Mst2 kinase and its regulation by RASSF5.},
  author={Lisheng Ni and Sheng Li and Jianzhong Yu and Jungki Min and Chad A. Brautigam and Diana R Tomchick and Duojia Pan and Xuelian Luo},
  journal={Structure},
  year={2013},
  volume={21 10},
  pages={1757-68}
}
The tumor-suppressive Hippo pathway controls tissue homeostasis through balancing cell proliferation and apoptosis. Activation of the kinases Mst1 and Mst2 (Mst1/2) is a key upstream event in this pathway and remains poorly understood. Mst1/2 and their critical regulators RASSFs contain Salvador/RASSF1A/Hippo (SARAH) domains that can homo- and heterodimerize. Here, we report the crystal structures of human Mst2 alone and bound to RASSF5. Mst2 undergoes activation through… CONTINUE READING
Highly Cited
This paper has 26 citations. REVIEW CITATIONS
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

Tumor suppressor C-RASSF proteins

Cellular and Molecular Life Sciences • 2018
View 4 Excerpts
Highly Influenced

Intrinsic protein disorder in oncogenic KRAS signaling

Cellular and Molecular Life Sciences • 2017

Similar Papers

Loading similar papers…