Structural basis for antagonism of human interleukin 18 by poxvirus interleukin 18-binding protein.

@article{Krumm2008StructuralBF,
  title={Structural basis for antagonism of human interleukin 18 by poxvirus interleukin 18-binding protein.},
  author={Brian Krumm and Xiangzhi Meng and Yongchao Li and Yan Xiang and Junpeng Deng},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 52},
  pages={20711-5}
}
Human interleukin-18 (hIL-18) is a cytokine that plays an important role in inflammation and host defense against microbes. Its activity is regulated in vivo by a naturally occurring antagonist, the human IL-18-binding protein (IL-18BP). Functional homologs of human IL-18BP are encoded by all orthopoxviruses, including variola virus, the causative agent of smallpox. They contribute to virulence by suppressing IL-18-mediated immune responses. Here, we describe the 2.0-A resolution crystal… CONTINUE READING
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