Structural basis for aminoglycoside inhibition of bacterial ribosome recycling

  title={Structural basis for aminoglycoside inhibition of bacterial ribosome recycling},
  author={M. A. Borovinskaya and R. Pai and W. Zhang and B. S. Schuwirth and J. Holton and G. Hirokawa and H. Kaji and A. Kaji and J. Cate},
  journal={Nature Structural &Molecular Biology},
  • M. A. Borovinskaya, R. Pai, +6 authors J. Cate
  • Published 2007
  • Biology, Medicine
  • Nature Structural &Molecular Biology
  • Aminoglycosides are widely used antibiotics that cause messenger RNA decoding errors, block mRNA and transfer RNA translocation, and inhibit ribosome recycling. Ribosome recycling follows the termination of protein synthesis and is aided by ribosome recycling factor (RRF) in bacteria. The molecular mechanism by which aminoglycosides inhibit ribosome recycling is unknown. Here we show in X-ray crystal structures of the Escherichia coli 70S ribosome that RRF binding causes RNA helix H69 of the… CONTINUE READING
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