Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin


A long-standing issue in the field of signal transduction is to understand the cross-talk between receptor tyrosine kinases (RTKs) and heterotrimeric G proteins, two major and distinct signaling hubs that control eukaryotic cell behavior. Although stimulation of many RTKs leads to activation of trimeric G proteins, the molecular mechanisms behind this… (More)
DOI: 10.1091/mbc.E14-05-0978