Structural basis for a pH-sensitive calcium leak across membranes

  title={Structural basis for a pH-sensitive calcium leak across membranes},
  author={Yanqi Chang and Renato Bruni and Brian T. Kloss and Zahra Assur and Edda Kloppmann and Burkhard Rost and Wayne A. Hendrickson and Qun Liu},
Calcium homeostasis balances passive calcium leak and active calcium uptake. Human Bax inhibitor–1 (hBI-1) is an antiapoptotic protein that mediates a calcium leak and is representative of a highly conserved and widely distributed family, the transmembrane Bax inhibitor motif (TMBIM) proteins. Here, we present crystal structures of a bacterial homolog and characterize its calcium leak activity. The structure has a seven-transmembrane-helix fold that features two triple-helix sandwiches wrapped… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 18 times over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 10 extracted citations

Similar Papers

Loading similar papers…