Structural basis for RNA replication by the hepatitis C virus polymerase

@article{Appleby2015StructuralBF,
  title={Structural basis for RNA replication by the hepatitis C virus polymerase},
  author={T. Appleby and Jason K. Perry and E. Murakami and O. Barauskas and Joy Y Feng and A. Cho and D. Fox and D. Wetmore and M. Mcgrath and A. Ray and M. Sofia and S. Swaminathan and T. Edwards},
  journal={Science},
  year={2015},
  volume={347},
  pages={771 - 775}
}
A view of the HCV polymerase at work More than 3% of the world's population is infected with hepatitis C virus (HCV), a predisposing factor for life-threatening liver diseases such as cirrhosis and cancer. HCV encodes a polymerase called NS5B that catalyzes replication of the viral RNA genome. Drugs inhibiting NS5B have shown impressive antiviral activity in recent clinical trials. Appleby et al. (see the Perspective by Bressanelli) reveal the inner workings of HCV RNA replication by analyzing… Expand
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