Structural basis for RNA replication by the hepatitis C virus polymerase

@article{Appleby2015StructuralBF,
  title={Structural basis for RNA replication by the hepatitis C virus polymerase},
  author={Todd C. Appleby and Jason K. Perry and Eisuke Murakami and Ona Barauskas and Joy Y. Feng and Aesop Cho and David Fox and Diana R. Wetmore and Mary E. Mcgrath and Adrian S. Ray and Michael J. Sofia and Swami Swaminathan and Thomas E Edwards},
  journal={Science},
  year={2015},
  volume={347},
  pages={771 - 775}
}
A view of the HCV polymerase at work More than 3% of the world's population is infected with hepatitis C virus (HCV), a predisposing factor for life-threatening liver diseases such as cirrhosis and cancer. HCV encodes a polymerase called NS5B that catalyzes replication of the viral RNA genome. Drugs inhibiting NS5B have shown impressive antiviral activity in recent clinical trials. Appleby et al. (see the Perspective by Bressanelli) reveal the inner workings of HCV RNA replication by analyzing… 

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