Structural basis for Epstein–Barr virus host cell tropism mediated by gp42 and gHgL entry glycoproteins

@inproceedings{Sathiyamoorthy2016StructuralBF,
  title={Structural basis for Epstein–Barr virus host cell tropism mediated by gp42 and gHgL entry glycoproteins},
  author={Karthik Sathiyamoorthy and Yao Xiong Hu and Britta S. M{\"o}hl and Jia Jie Chen and Richard Longnecker and Theodore S. Jardetzky},
  booktitle={Nature communications},
  year={2016}
}
Herpesvirus entry into host cells is mediated by multiple virally encoded receptor binding and membrane fusion glycoproteins. Despite their importance in host cell tropism and associated disease pathology, the underlying and essential interactions between these viral glycoproteins remain poorly understood. For Epstein-Barr virus (EBV), gHgL/gp42 complexes bind HLA class II to activate membrane fusion with B cells, but gp42 inhibits fusion and entry into epithelial cells. To clarify the… CONTINUE READING
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