Structural basis for DNA recognition by the human PAX3 homeodomain.

@article{Birrane2009StructuralBF,
  title={Structural basis for DNA recognition by the human PAX3 homeodomain.},
  author={G. Birrane and A. Soni and J. Ladias},
  journal={Biochemistry},
  year={2009},
  volume={48 6},
  pages={
          1148-55
        }
}
The transcription regulatory protein PAX3 binds to cognate DNA sequences through two DNA-binding domains, a paired domain and a homeodomain, and has important functions during neurogenesis and myogenesis. In humans, mutations in the PAX3 gene cause Waardenburg syndrome, whereas a chromosomal translocation that generates a PAX3-FOXO1 fusion gene is associated with the development of alveolar rhabdomyosarcoma. We have determined the crystal structure of the human PAX3 homeodomain in complex with… Expand
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