Structural basis for DNA-cleaving activity of resveratrol in the presence of Cu(II).

@article{Fukuhara2006StructuralBF,
  title={Structural basis for DNA-cleaving activity of resveratrol in the presence of Cu(II).},
  author={K. Fukuhara and M. Nagakawa and I. Nakanishi and K. Ohkubo and K. Imai and S. Urano and S. Fukuzumi and T. Ozawa and N. Ikota and M. Mochizuki and N. Miyata and H. Okuda},
  journal={Bioorganic \& medicinal chemistry},
  year={2006},
  volume={14 5},
  pages={
          1437-43
        }
}
Resveratrol (1, 3,5,4'-trihydroxy-trans-stilbene), a polyphenol found in grapes and other food products, is known as an antioxidant and cancer chemopreventive agent. However, 1 was shown to induce genotoxicity through a high frequency of micronucleus and sister chromatid exchange in vitro and DNA-cleaving activity in the presence of Cu(II). The present study was designed to explore the structure-activity relationship of 1 in DNA strand scission and to characterize the substrate specificity for… Expand
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  • 2008
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