Structural bases for the inhibition of aldose reductase by phenolic compounds.

@article{Rastelli2000StructuralBF,
  title={Structural bases for the inhibition of aldose reductase by phenolic compounds.},
  author={Giulio Rastelli and Luciano Antolini and Stefania Benvenuti and Luca Costantino},
  journal={Bioorganic & medicinal chemistry},
  year={2000},
  volume={8 5},
  pages={1151-8}
}
Aldose reductase (ALR2) is an enzyme involved in the development of long-term diabetic complications. In the search for aldose reductase inhibitors less acidic than carboxylic acids, phenolic compounds related to benzopyran-4-one and chalcone are particularly interesting because they possess good inhibitory properties. In order to investigate the similarities between these two classes of compounds and to provide a structural basis for their inhibition of ALR2, the existing structure-activity… CONTINUE READING
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