Structural assessment of the effects of Amino Acid Substitutions on protein stability and protein-protein interaction

@article{Teng2010StructuralAO,
  title={Structural assessment of the effects of Amino Acid Substitutions on protein stability and protein-protein interaction},
  author={Shaolei Teng and Anand K. Srivastava and Charles E. Schwartz and Emil Alexov and Liangjiang Wang},
  journal={International journal of computational biology and drug design},
  year={2010},
  volume={3 4},
  pages={
          334-49
        }
}
A structure-based approach is described for predicting the effects of amino acid substitutions on protein function. Structures were predicted using a homology modelling method. Folding and binding energy differences between wild-type and mutant structures were computed to quantitatively assess the effects of amino acid substitutions on protein stability and protein protein interaction, respectively. We demonstrated that pathogenic mutations at the interaction interface could affect binding… 

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