Structural assembly of the signaling competent ERK2-RSK1 heterodimeric protein kinase complex.

  title={Structural assembly of the signaling competent ERK2-RSK1 heterodimeric protein kinase complex.},
  author={Anita Alexa and Gergő G{\'o}gl and G{\'a}bor Glatz and {\'A}gnes Garai and Andr{\'a}s Zeke and J{\'a}nos Varga and Erika Dud{\'a}s and Norbert Jeszenoi and Andrea Bodor and Csaba Het{\'e}nyi and Attila Rem{\'e}nyi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={112 9},
Mitogen-activated protein kinases (MAPKs) bind and activate their downstream kinase substrates, MAPK-activated protein kinases (MAPKAPKs). Notably, extracellular signal regulated kinase 2 (ERK2) phosphorylates ribosomal S6 kinase 1 (RSK1), which promotes cellular growth. Here, we determined the crystal structure of an RSK1 construct in complex with its activator kinase. The structure captures the kinase-kinase complex in a precatalytic state where the activation loop of the downstream kinase… CONTINUE READING


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