Structural assembly of cullin-RING ubiquitin ligase complexes.

@article{Zimmerman2010StructuralAO,
  title={Structural assembly of cullin-RING ubiquitin ligase complexes.},
  author={Erik S. Zimmerman and Brenda Arlene Schulman and Ning Zheng},
  journal={Current opinion in structural biology},
  year={2010},
  volume={20 6},
  pages={
          714-21
        }
}
The cullin-RING ubiquitin ligases (CRLs) are the largest family of multi-subunit E3 ligases in eukaryotes, which ubiquitinate protein substrates in numerous cellular pathways. CRLs share a common arched scaffold and a RING domain catalytic subunit, but use different adaptors and substrate receptors to assemble unique E3 machineries. In comparison to the first CRL structure, recent findings have revealed increased complexity in the overall architecture and assembly mode of CRLs, including multi… CONTINUE READING

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