Structural aspects of the sarcoplasmic reticulum K+ channel revealed by gallamine block.

@article{Gray1988StructuralAO,
  title={Structural aspects of the sarcoplasmic reticulum K+ channel revealed by gallamine block.},
  author={Michael A. Gray and Barbara Tomlins and Richard A. P. Montgomery and Alan R. Williams},
  journal={Biophysical journal},
  year={1988},
  volume={54 2},
  pages={233-9}
}
We have studied single-channel conductance fluctuations of K+ channels present in the sarcoplasmic reticulum (SR) membrane systems of rabbit cardiac and skeletal muscle. K+ conductance through the channels is reversibly blocked by gallamine. Conductance block occurs only from the trans side of the channel and is resolved as a smooth reduction in the open state conductance. At a fixed K+ concentration, conduction decreases with increasing gallamine concentration and the data can be fitted to a… CONTINUE READING

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