Structural aspects of rabies virus replication

@article{Albertini2007StructuralAO,
  title={Structural aspects of rabies virus replication},
  author={Aur{\'e}lie A Albertini and Guy Schoehn and Winfried Weissenhorn and Rob W. H. Ruigrok},
  journal={Cellular and Molecular Life Sciences},
  year={2007},
  volume={65},
  pages={282-294}
}
Abstract.Rabies virus is a negative-strand RNA virus. Its RNA genome is condensed by the viral nucleoprotein (N), and it is this N-RNA complex that is the template for transcription and replication by the viral RNA-dependent RNA polymerase complex. Here we discuss structural and functional aspects of viral transcription and replication based on the atomic structure of a recombinant rabies virus N-RNA complex. We situate available biochemical data on N-RNA interactions with viral and cellular… 
Structural disorder in proteins of the rhabdoviridae replication complex.
TLDR
The modular organization of P is described based on recent structural, biophysical and bioinformatics data and it is shown how flexible loops in N participate in the attachment of P to the N-RNA template by an induced- fit mechanism.
Uncovering Viral Protein-Protein Interactions and their Role in Arenavirus Life Cycle
TLDR
Current evidence suggests that binding between Z and the viral envelope glycoprotein complex is required for virion infectivity, and that Z homo-oligomerization is an essential step for particle assembly and budding.
Crystal Structure of a Nucleocapsid-Like Nucleoprotein-RNA Complex of Respiratory Syncytial Virus
TLDR
The three-dimensional crystal structure at 3.3 Å resolution of a decameric, annular ribonucleoprotein complex of the RSV nucleoprotein (N) bound to RNA is determined, which mimics one turn of the viral helical nucleocapsid complex, which serves as template for viral RNA synthesis.
Structure of the Nucleoprotein Binding Domain of Mokola Virus Phosphoprotein
TLDR
A structure for this domain of MOKV P is presented, obtained by expression of full-length P in Escherichia coli, which was subsequently truncated during crystallization and a potential binding site for the nucleoprotein N is revealed.
A versatile building block: the structures and functions of negative-sense single-stranded RNA virus nucleocapsid proteins
TLDR
Structural investigations show that -ssRNA viruses that encode NPs preliminarily serve as structural building blocks that encapsidate and protect the viral genomicRNA and mediate the interaction between genomic RNA and RNA-dependent RNA polymerase.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 84 REFERENCES
Crystal Structure of the Rabies Virus Nucleoprotein-RNA Complex
TLDR
RNA sequestering by nucleoproteins is likely a common mechanism used by negative-strand RNA viruses to protect their genomes from the innate immune response directed against viral RNA in human host cells at certain stages of an infectious cycle.
The specificity of rabies virus RNA encapsidation by nucleoprotein.
TLDR
Investigation of the interaction between rabies virus N and the positive-strand leader RNA transcript revealed that recombinant N binds preferentially to rabiesirus leader RNA and that N binding to leader RNA was 5 to 10 times stronger than to nonleader RNA.
Structure of the Vesicular Stomatitis Virus Nucleoprotein-RNA Complex
TLDR
A 2.9 angstrom structure of a complex containing 10 molecules of the N protein and 90 bases of RNA is determined, which serves to protect the RNA in the absence of polynucleotide synthesis.
Isolation and Characterisation of the Rabies Virus N°-P Complex Produced in Insect Cells
TLDR
This work coexpressed rabies virus N and P proteins in insect cells and purified the N°-P complex, a soluble complex that consists of one N protein plus two P proteins, i.e., an N-P2 complex.
Structure of Recombinant Rabies Virus Nucleoprotein-RNA Complex and Identification of the Phosphoprotein Binding site
TLDR
A low-resolution model for rabies virus N-RNA in the virus is proposed based on the shape of N determined here and on structural parameters derived from electron microscopy on free rabiesirus N- RNA and from nucleocapsid in virus.
Isolation and characterisation of the rabies virus N degrees-P complex produced in insect cells.
TLDR
Characterisation by gel filtration, polyacrylamide gel electrophoresis, analytical ultracentrifugation, native mass spectroscopy, and electron microscopy showed that the complex consists of one N protein plus two P proteins, i.e., an N degrees -P(2) complex.
Morphology of Marburg virus NP-RNA.
TLDR
Electron microscopy of fixed Marburg virus particles shows that the viral nucleocapsid has a smaller diameter than the free, recombinant NP-RNA, a characteristic observed for other nonsegmented negative-strand virus N-RNAs.
...
1
2
3
4
5
...