Structural aspects of protein kinase control-role of conformational flexibility.

@article{Engh2002StructuralAO,
  title={Structural aspects of protein kinase control-role of conformational flexibility.},
  author={Richard Alan Engh and Dirk Bossemeyer},
  journal={Pharmacology & therapeutics},
  year={2002},
  volume={93 2-3},
  pages={99-111}
}
Protein kinases catalyze the phosphotransfer reaction fundamental to most signaling and regulatory processes in the eukaryotic cell. Absolute control of individual protein kinase activity is, therefore, of utmost importance to signaling fidelity in the cell. Mechanisms for activity modulation, including complete and reversible inactivation, have been shown by crystal structures of many active and inactive protein kinases. The structures of inactivated kinases, compared with those of active and… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

Similar Papers

Loading similar papers…