Structural aspects of antioxidant activity of flavonoids.

@article{Acker1996StructuralAO,
  title={Structural aspects of antioxidant activity of flavonoids.},
  author={S. V. van Acker and D. J. van den Berg and M. N. Tromp and D. Griffioen and W. P. van Bennekom and W. van der Vijgh and A. Bast},
  journal={Free radical biology \& medicine},
  year={1996},
  volume={20 3},
  pages={
          331-42
        }
}
Flavonoids, a group of naturally occurring antioxidants and iron chelators, might be used as cardioprotective agents in doxorubicin-induced cardiotoxicity, which is believed to be caused by the formation of oxygen free radicals. To investigate the underlying molecular mechanism, we tested a large group of flavonoids from all major structural subclasses on their ability to inhibit doxorubicin (enzymatically)-induced and Fe2+/ascorbate (nonenzymatically)-induced microsomal lipid peroxidation (LPO… Expand
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