Structural aspects of a higher order nucleoprotein complex: induction of an altered DNA structure at the Mu-host junction of the Mu type 1 transpososome.

@article{Lavoie1991StructuralAO,
  title={Structural aspects of a higher order nucleoprotein complex: induction of an altered DNA structure at the Mu-host junction of the Mu type 1 transpososome.},
  author={Brigitte D. Lavoie and Benedict Shiu-Shing Chan and Richard G Allison and George Chaconas},
  journal={The EMBO journal},
  year={1991},
  volume={10 10},
  pages={3051-9}
}
The Mu in vitro strand transfer reaction proceeds via two stable higher order nucleoprotein complexes, the Type 1 and Type 2 transpososomes. The Mu A protein is responsible for the structural and functional integrity of the Type 1 transpososome. We have investigated the quaternary structure of the Mu A protein within this complex by chemical cross-linking experiments and found that the basic structural unit is an A tetramer. Three Mu A binding sites in the transpososome are protected by DNase I… CONTINUE READING

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