Structural aspects and physiological consequences of APP/APLP trans-dimerization

Abstract

The amyloid precursor protein (APP) is one of the key proteins in Alzheimer’s disease (AD), as it is the precursor of amyloid β (Aβ) peptides accumulating in amyloid plaques. The processing of APP and the pathogenic features of especially Aβ oligomers have been analyzed in detail. Remarkably, there is accumulating evidence from cell biological and… (More)
DOI: 10.1007/s00221-011-2878-6

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