Structural arrangement of DNA constrained by a cross-linker.

Abstract

Self-complementary cross-linked oligonucleotides with a disulfide linkage were designed and synthesized. Double helix and hairpin structures were controlled using the different diastereochemistry of phosphoramidate where the cross-linker was introduced. The structures of the strained cross-linked DNAs were estimated by gel mobility, circular dichroism spectra, and melting profiles.

Cite this paper

@article{Endo2005StructuralAO, title={Structural arrangement of DNA constrained by a cross-linker.}, author={Masayuki Endo and Tetsuro Majima}, journal={Organic & biomolecular chemistry}, year={2005}, volume={3 19}, pages={3476-8} }