Structural and thermodynamic correlates of T cell signaling.

  title={Structural and thermodynamic correlates of T cell signaling.},
  author={Markus G. Rudolph and John Gately Luz and Ian A. Wilson},
  journal={Annual review of biophysics and biomolecular structure},
The first crystal structures of intact T cell receptors (TCRs) bound to class I peptide-MHC (pMHCs) antigens were determined in 1996. Since then, further structures of class I TCR/pMHC complexes have explored the degree of structural variability in the TCR-pMHC system and the structural basis for positive and negative selection. The recent determination of class II and allogeneic class I TCR/pMHC structures, as well as those of accessory molecules (e.g., CD3), has pushed our knowledge of TCR… CONTINUE READING


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