Structural and thermodynamic consequences of 1-(4-chlorophenyl)imidazole binding to cytochrome P450 2B4.

@article{Zhao2007StructuralAT,
  title={Structural and thermodynamic consequences of 1-(4-chlorophenyl)imidazole binding to cytochrome P450 2B4.},
  author={Yonghong Zhao and Ling Sun and Bilikallahalli K Muralidhara and Santosh Kumar and Mark A White and Charles David Stout and James R. Halpert},
  journal={Biochemistry},
  year={2007},
  volume={46 41},
  pages={
          11559-67
        }
}
The crystal structure of P450 2B4 bound with 1-(4-chlorophenyl)imidazole (1-CPI) has been determined to delineate the structural basis for the observed differences in binding affinity and thermodynamics relative to 4-(4-chlorophenyl)imidazole (4-CPI). Compared with the previously reported 4-CPI complex, there is a shift in the 1-CPI complex of the protein backbone in helices F and I, repositioning the side chains of Phe-206, Phe-297, and Glu-301, and leading to significant reshaping of the… CONTINUE READING
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Structure - function analysis of cytochromes P 450 2 B

  • J. R. Halpert
  • Biochim . Biophys . Acta
  • 2007