Structural and thermodynamic characterization of pre- and postpolymerization states in the F4 fimbrial subunit FaeG.


Enterotoxigenic Escherichia coli expressing F4 fimbriae are the major cause of porcine colibacillosis and are responsible for significant death and morbidity in neonatal and postweaned piglets. Via the chaperone-usher pathway, F4 fimbriae are assembled into thin, flexible polymers mainly composed of the single-domain adhesin FaeG. The F4 fimbrial system has… (More)
DOI: 10.1016/j.jmb.2009.09.059

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