Structural and thermodynamic basis of (+)-α-pinene binding to human cytochrome P450 2B6.

  title={Structural and thermodynamic basis of (+)-α-pinene binding to human cytochrome P450 2B6.},
  author={P Ross Wilderman and Manish B Shah and Hyun-Hee Jang and Charles David Stout and James R. Halpert},
  journal={Journal of the American Chemical Society},
  volume={135 28},
Despite recent advances in atomic-level understanding of drug and inhibitor interactions with human cytochromes P450, the decades-old questions of chemical and structural determinants of hydrocarbon binding are still unanswered. (+)-α-Pinene is a monoterpene hydrocarbon that is widely distributed in the environment and a potent P450 2B inhibitor. Therefore, a combined biophysical and structural analysis of human P450 2B6 interactions with (+)-α-pinene was undertaken to elucidate the basis of… CONTINUE READING
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