Structural and sequential context of p53: A review of experimental and theoretical evidence.

@article{Saha2015StructuralAS,
  title={Structural and sequential context of p53: A review of experimental and theoretical evidence.},
  author={Taniya Saha and Rajiv Kumar Kar and Gaurisankar Sa},
  journal={Progress in biophysics and molecular biology},
  year={2015},
  volume={117 2-3},
  pages={
          250-263
        }
}
Approximately 27 million people are suffering from cancer that contains either an inactivating missense mutation of TP53 gene or partially abrogated p53 signaling pathway. Concerted action of folded and intrinsically disordered domains accounts for multi-faceted role of p53. The intricacy of dynamic p53 structure is believed to shed light on its cellular activity for developing new cancer therapies. In this review, insights into structural details of p53, diverse single point mutations… CONTINUE READING
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