Structural and resting-state MRI detects regional brain differences in young and mid-age healthy APOE-e4 carriers compared with non-APOE-e4 carriers.

@article{Dowell2016StructuralAR,
  title={Structural and resting-state MRI detects regional brain differences in young and mid-age healthy APOE-e4 carriers compared with non-APOE-e4 carriers.},
  author={Nicholas G. Dowell and Simon Evans and Paul S. Tofts and S. L. King and Naji Tabet and J. M. Rusted},
  journal={NMR in biomedicine},
  year={2016},
  volume={29 5},
  pages={614-24}
}
The presence of the e4 allele of the apolipoprotein E (APOE) gene is the best-known genetic risk factor for Alzheimer's disease. In this study, we investigated the link between functional and behavioural differences and regional brain volume and cortical thickness differences in those who carry the e4 allele (e4+) and those who only carry the e3 allele (e3/e3). We studied these genotype populations in two age groups: a young group (average age, 21 years) and a mid-age group (average age, 50… CONTINUE READING

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