Structural and regulatory functions of keratins.

@article{Magin2007StructuralAR,
  title={Structural and regulatory functions of keratins.},
  author={T. Magin and P. Vijayaraj and R. Leube},
  journal={Experimental cell research},
  year={2007},
  volume={313 10},
  pages={
          2021-32
        }
}
The diversity of epithelial functions is reflected by the expression of distinct keratin pairs that are responsible to protect epithelial cells against mechanical stress and to act as signaling platforms. The keratin cytoskeleton integrates these functions by forming a supracellular scaffold that connects at desmosomal cell-cell adhesions. Multiple human diseases and murine knockouts in which the integrity of this system is destroyed testify to its importance as a mechanical stabilizer in… Expand
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