Structural and physicochemical characterization of the inclusion complexes of cyclomaltooligosaccharides (cyclodextrins) with melatonin.

@article{Bongiorno2002StructuralAP,
  title={Structural and physicochemical characterization of the inclusion complexes of cyclomaltooligosaccharides (cyclodextrins) with melatonin.},
  author={David Bongiorno and Leopoldo Ceraulo and Andrea Mele and Walter Panzeri and Antonio Selva and Vincenzo Turco Liveri},
  journal={Carbohydrate research},
  year={2002},
  volume={337 8},
  pages={743-54}
}
The stoichiometry, geometry, stability, and solubility of the inclusion complexes of melatonin (MLT) with native cyclomaltooligosaccharides (alpha-, beta- or gamma-cyclodextrins, CDs) are determined experimentally by high-resolution NMR spectroscopy, calorimetric and solubility measurements, and mass spectrometry. The observed differences are discussed in terms of molecular recognition expression of the host-guest (h-g) interactions within the hydrophobic CDs cavities of different size. The 1:1… CONTINUE READING