Structural and pharmacological basis for the induction of mitochondrial biogenesis by formoterol but not clenbuterol

Abstract

Mitochondrial dysfunction is associated with numerous acute and chronic degenerative diseases. The beta-2 adrenergic receptor (β2AR) agonist formoterol induces mitochondrial biogenesis (MB), but other β2AR agonists, such as clenbuterol, do not. We sought to identify the MB signaling pathway of formoterol and the differences in signaling between these two… (More)
DOI: 10.1038/s41598-017-11030-5

Topics

7 Figures and Tables