Structural and mechanistic studies of polymerase η bypass of phenanthriplatin DNA damage

  • Mark T. Gregorya, Ga Young Parkc, +3 authors Stephen J. Lippardc
  • Published 2014
Platinum drugs are a mainstay of anticancer chemotherapy. Nevertheless, tumors often display inherent or acquired resistance to platinum-based treatments, prompting the search for new compounds that do not exhibit cross-resistance with current therapies. Phenanthriplatin, cis-diamminephenanthridinechloroplatinum(II), is a potent monofunctional platinum… CONTINUE READING