Structural and mechanistic insight into N-glycan processing by endo-α-mannosidase.

  title={Structural and mechanistic insight into N-glycan processing by endo-α-mannosidase.},
  author={Andrew J Thompson and Rohan J Williams and Zalihe Hakki and Dominic S. Alonzi and Tom Wennekes and Tracey M Gloster and Kriangsak Songsrirote and Jane E. Thomas-Oates and Tanja M Wrodnigg and Josef Spreitz and Arnold E. St{\"u}tz and Terry D. Butters and Spencer J Williams and Gideon J Davies},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={109 3},
N-linked glycans play key roles in protein folding, stability, and function. Biosynthetic modification of N-linked glycans, within the endoplasmic reticulum, features sequential trimming and readornment steps. One unusual enzyme, endo-α-mannosidase, cleaves mannoside linkages internally within an N-linked glycan chain, short circuiting the classical N-glycan biosynthetic pathway. Here, using two bacterial orthologs, we present the first structural and mechanistic dissection of endo… CONTINUE READING
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