Structural and mechanistic insight into N-glycan processing by endo-α-mannosidase.

@article{Thompson2012StructuralAM,
  title={Structural and mechanistic insight into N-glycan processing by endo-α-mannosidase.},
  author={Andrew J Thompson and Rohan J Williams and Zalihe Hakki and Dominic S. Alonzi and Tom Wennekes and Tracey M Gloster and Kriangsak Songsrirote and Jane E. Thomas-Oates and Tanja M Wrodnigg and Josef Spreitz and Arnold E. St{\"u}tz and Terry D. Butters and Spencer J Williams and Gideon J Davies},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 3},
  pages={781-6}
}
N-linked glycans play key roles in protein folding, stability, and function. Biosynthetic modification of N-linked glycans, within the endoplasmic reticulum, features sequential trimming and readornment steps. One unusual enzyme, endo-α-mannosidase, cleaves mannoside linkages internally within an N-linked glycan chain, short circuiting the classical N-glycan biosynthetic pathway. Here, using two bacterial orthologs, we present the first structural and mechanistic dissection of endo… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 39 references

Analysis of a new family of widely distributed metal-independent α-Mannosidases provides unique insight into the processing of N-linked glycans

  • KJ Gregg
  • J Biol Chem
  • 2011

Mechanistic insights into a calcium-dependent family of α-mannosidases in a human gut symbiont

  • Y Zhu
  • Nat Chem Biol
  • 2010

Protective effect of N-glycan bisecting GlcNAc residues on beta-amyloid production in Alzheimer’s disease

  • K Akasaka-Manya
  • Glycobiology
  • 2010

Functional roles of N-glycans in cell signaling and cell adhesion in cancer

  • YY Zhao
  • Cancer Sci 99:1304–1310
  • 2008

Similar Papers

Loading similar papers…