Structural and kinetic molecular dynamics study of electroporation in cholesterol-containing bilayers.

@article{Fernndez2010StructuralAK,
  title={Structural and kinetic molecular dynamics study of electroporation in cholesterol-containing bilayers.},
  author={Mar{\'i}a Laura Fern{\'a}ndez and Guillermo Marshall and Francesc Sagu{\'e}s and Ramon Reigada},
  journal={The journal of physical chemistry. B},
  year={2010},
  volume={114 20},
  pages={6855-65}
}
We present a numerical study of pore formation in lipid bilayers containing cholesterol (Chol) and subjected to a transverse electric field. Molecular dynamics simulations of 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DOPC) membranes reveal the formation of a pore when an electric field of 325 mV/nm is applied. The minimum electric field needed for membrane permeabilization strongly increases with the addition of cholesterol above 10 mol %, reaching 750 mV/nm for 40 mol % Chol. Analysis… CONTINUE READING

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